Electron Microscopy Facility

Prof. Saeed Akhtar runs the electron microscopy facility

Equipment

  • Transmission electron microscope JOEL JEM 1400 (HC)
  • Xarosa 20 Mega Pixel Bottom Mount CCD Camera
  • Veleta G3 4 Mega Pixel Side Mount Camera
  • Specimen Quartet Holder to observe 4 specimens without moving out of the specimen holder
  • Specimen Quick Change Holder – to observe specimens at a very high magnification (x500,000)
  • Specimen High Tilting Holder to tilt specimens from -70 degrees to +70 degree to capture 140 images for tomography
  • Tomography System with computers

 

Software

  • Radius software to capture ultrastructural images at a magnification up to a million
  • Recorder software to capture 140 images at 80,000 magnifications from -70 to +70 degree
  • Composer software to compose all the 140 images into 3D image format
  • Visualizer-Kai software to colour code the 3D image

 

Research

We have expertise to carry out Ultrastructural and 3D tomography research on normal and pathological biological tissue. Our main focus on the ultrastructural organization and 3D electron tomography of collagen fibrils and proteoglycans of normal and pathological cornea such as keratoconus (see picture).  We have published our findings in high impact peer-review articles. We also carry out research on the retina, optic nerve, intervertebral disc, knee cartilage and heart valve.

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